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Esomeprazole provides improved acid control in patients with gastroesophageal reflux disease. Nexium is a type of medicine known as an acid pump inhibitor which works by decreasing the acid produced by acid pumps. Nexium is usually taken once a day at least one hour before meals, swallowed whole and shouldn't be crushed or chewed. What should my health care professional know before I take Esomeprazole? By your doctor. Our website, all orders are confidential.